The Monaghan Lab

 

Researching Regeneration

The Monaghan Lab at Northeastern University studies how axolotls regrow severed limbs and repair injured organs. 

Our Goal

Understand the cellular and molecular underpinnings of regeneration so that this knowledge can one day be applied to treating injuries and disease in humans.

Monaghan Lab Research

Lung Regeneration

We are studying the cellular and molecular basis of axolotl lung regeneration using scRNAseq, lineage tracing, and functional gene testing. 

Limb Development and Patterning

We use V3 HCR FISH and a genetic engineering tool CRISPR/Cas9 to understand how retinoic acid controls axolotl limb growth.

Mechanobiology of Joint Morphogenesis

In collaboration with the Shefelbine lab, we combine research on developing and regenerating axolotl limbs with predictive computational models to understand how mechanical forces trigger cellular signaling responses and change joint shape.

The Monaghan Lab

Northeastern University

360 Huntington Avenue

Boston, MA 02115

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